Best personal antivirus software?

A poster on the tech forums at http://forums.somethingawful.com/ recently asked for everyone's opinions about what the best personal antivirus software is. Best defined as, "cleanest and fastest", using the fewest resources and so forth.

The majority opinion seemed to lean toward a program called NOD32 - one user said about it:

"Another vote for Nod32. I had the trial version and it was the best antivirus program I've used so far. I have used F-secure, Norton, McAfee and AntiVir before. I especially like how Nod32 understands to stay in the background and keep its "mouth" shut without constant popups and annoying stuff, which are so common with many other antivirus programs."

I still don't use antivirus on my home computers because I'm flat out too smart to download anything that would put me in danger, but if I did, I'd probably go with this.

Avast! Antivirus is also a good choice.  It runs in 32bit and 64bit environments alike, which is always a plus.

Trend is a great product, we use OfficeScan and ServerProtect in our office on our client PC's and Servers.  One of the Trend suites is also what we recommend to all our clients, which trend suite depends on the customer and size of the LAN and requirements.